Isoniazid for preventing tuberculosis in HIV‐infected children
Zunza M, Gray DM, Young T, Cotton M, Zar HJ. Isoniazid for preventing tuberculosis in HIV‐infected children. Cochrane Database of Systematic Reviews 2017, Issue 8. Art. No.: CD006418. DOI: 10.1002/14651858.CD006418.pub3.
Abstract: Tuberculosis (TB) is an important cause of illness and death in HIV‐positive children living in areas of high TB prevalence. We know that isoniazid prophylaxis prevents TB in HIV‐negative children following TB exposure, but there is uncertainty related to its role in TB preventive treatment in HIV‐positive children. The objective was to summarise the effects of TB preventive treatment versus placebo in HIV‐positive children with no known TB contact on active TB, death, and reported adverse events. The authors conclude that isoniazid prophylaxis given to all children diagnosed with HIV may reduce the risk of active TB and death in HIV‐positive children not on ART in studies from Africa. For children on ART, no clear benefit was detected.
Author(s): Cochrane Database of Systematic Reviews
Region(s): SOUTH AFRICA
Resource Type: Journal Articles